us arising through the production of extended –

us mirabilis (P. mirabilis) is a motile gramnegative
bacterium belonging to the family
Enterobacteriaceae. It is indole negative,
chloramphenicol and ampicillin sensitive (1), (2).
Members of the Enterobacteriaceae, are all oxidase
negative, actively motile, non-spore forming, non-capsulated
and a recognized by their ability to cause disease (3).
The organism occurs widely in man, animals and in the
environment and can be readily recovered from sewage, soil,
garden vegetables and many other materials (2).
P. mirabilis is the species most commonly recovered from
humans, especially from urinary and wound infections and
accounts for 90% of all infections caused by the Proteus
species (3).
Urinary tract infections (UTIs) are one of the most
common infectious diseases, and nearly 10% of people will
experience a UTI during their life time. The infections may be
symptomatic or asymptomatic, and types of infection can
result in serious sequelae if left untreated (4).
Although several different microorganisms can cause
UTIs, including fungi and viruses, bacteria are the major
causative organisms and are responsible for more than 95% of
UTI cases (4).
P. mirabilis is a common cause of hospital acquired UTIs
and it can also cause infection in nonhospitalized patients,
especially those with staghorn (struvite) calculi, structural
urinary tract abnormalities or an indwelling catheter (1).
Like many members of the family Enterobacteriaceae,
Proteus species can harbor numerous plasmid – and integron –
mediated antimicrobial resistance determinants (5).
The increase in the number of resistant and multiresistant
(resistant to two and more antimicrobials) strains of bacteria is
a major concern of health officials worldwide. Recently,
bacterial resistance arising through the production of extended
– spectrum beta – lactamases (ESBLs) has been recognized as
a worldwide therapeutic problem (6). The mechanisms of this
resistance are often complex, and include production of ?-
lactamases, unr

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