The phytochemical analysis of the plants is very important commercially as it is of great interest in pharmaceutical companies for the production of the new drugs for curing of various diseases. It is expected that the important phytochemical properties recognized by our study in the indigenous medicinal plants The present study revealed that O sanctum leaf extacts could be a better alternate against most of the gram positive bacteria analyzed in present investigation when compared to other leaves.In future screening of antibacterial component of these plants will lead to establish pharmaceutically important therapeutics for the formulation of the new drugs in the health care need.This work chains the traditional use of these plants and the useful value against bacterial pathogens, so that they can be exchange antibacterial agents in future.