Cladosporium is a mold with pigment, found to be airborne or on rotten organic matter both indoors and outdoors. They are slow-growing. Some species may be resistant. Exposures to the spores cause hypersensitivity pneumonitis, respiratory allergies and allergic rhinitis. Other aligments include skin lesions sinusitis, keratitis and nail fungus ………….Colletotrichum musae is a plant pathogen primarily affecting the genus Musa (Musa is one of two or three genera in the family Musaceae, it includes bananas and plantains. Around 70 species of Musa are known, with a broad variety of uses), which includes bananas and plantains. It is best known as a cause of anthracnose (the black and brown spots) indicating ripeness on bananas …………The importance of identifying the pathogenic fungi rapidly has encouraged the development of differential media for the presumptive identification of yeasts. C. albicans is opportunistic pathogenic yeast. It is a common member of the human gut flora. It does not proliferate outside the human body. C. albicans is cause symptoms including joint pain, weight gain, fatigue, and gas. C. albicans are establishing fast growing colonies, biofilms and starting to dominate human gut. So, population can get out of control because they. Toxic byproducts they cause damage to body organs and tissues. They can cause unpleasant symptoms as headaches and nausea ……………… ……….It is a round shaped, a gram-positive bacterium. It is a member of the normal flora of the body, found in the nose, respiratory tract, and on the skin. It is often positive for catalase and nitrate reduction and is a facultative anaerobe. S. aureus is not always pathogenic.It causes skin infections, abscesses, sinusitis and food poisoning. The emergence of antibiotic-resistant strains of S. aureus such as methicillin-resistant S. aureus (MRSA) is a worldwide problem in clinical medicine. Pathogenicity MRSA is an emerging cause of infections outside of healthcare settings. Skin infection and necrotizing pneumonia have been reported as the cases of infections caused by MRSA ,,,,,,,,,,,,,,,,,,,,,,,It is a Gram-negative bacterium. Cell structure is rod-shaped. P. aeruginosa can cause disease in plants and animals. It is a medically important species. P. aeruginosa is a multidrug resistant pathogen recognized, advanced antibiotic resistance mechanisms. P. aeruginosa associated with illnesses hospital acquired infections. Such as ventilator associated pneumonia and various sepsis syndromes. P. aeruginosa is cause cystic fibrosis and traumatic burns. Treatment of P. aeruginosa infections difficult because it has natural resistance to antibiotics ,,,,,,,,,,,,,,,,,,,,E. coli is a Gram-negative, facultative, rod-shaped, anaerobic, coliform bacterium of the genus Escherichia. That is commonly found in the lower intestine of warm-blooded organisms. Most strains are harmless. Some serotypes can cause food poisoning. Due to food contamination they are occasionally responsible for product recalls. The harmless strains are part of the normal flora of the gut. Also they can benefit their hosts by producing vitamin K2. E. coli are preventing colonization of the intestine with pathogenic bacteria. They have a symbiotic relationship. They expelled into the environment within fecal matter. E. coli grows massively in fresh fecal matter under aerobic conditions. Its numbers decline slowly afterwards ,,,,,,,,,,,,,,,,,,,,,,,,,,,,Phytochemicals are non-nutritive plant chemicals. They have protective or disease preventive properties. There are more than thousand known phytochemicals. They are non-essential nutrients, because that they are not required by the human body for sustaining life. It is well-known that plant produces these chemicals to protect them. But recent researches demonstrate that they can also protect humans against diseases. There are many phytochemicals and each works differently. Some possible actions are antioxidant, hormonal action, stimulation of enzymes, interference with DNA replication, anti-bacterial effect and physical action.