1. prostaglandins and thromboxanes. Other functions of

1. Cyclo-oxygenase inhibitors (COX inhibitors)the drugs have the following effects:Anti inflammatory action: they provide symptomatic relief from pain and swelling in chronic joint disease i.e. in osteo-arthritis and rheumatoid arthritis. They decrease prostaglandin E2 and prostacyclin reduces vasodilation and, indirectly, oedema. However, the inflammatory cells are not directly reduced.

Analgesic action: it reduces headaches by decreasing prostaglandin mediated vasodilation. This is through the reduction of prostaglandin generation making the nociceptive nerve endings less sensitive to inflammatory mediators like bradykinins and 5-hydroxytryptamine.Antipyretic action: NSAIDs prevent the release of prostaglandins from interleukin-1 in the central nervous system. This reduces the hypothalamic set point for temperature control, thereby reducing fever.Examples of NSAIDs are:- aspirin, ibuprofen, naproxen, indomethacin, piroxicam.Many NSAID’s have different functions and composition but they primarily target fatty acid COX enzymes and thereby inhibiting the production of prostaglandins and thromboxanes.

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Other functions of NSAID’s in inflammatory effects are: • Inhibition of vasodilation and oedema to reduce peripheral COX-2-generated prostaglandin synthesis • Reduce harmful superoxide free radical generation by neutrophils and macrophages • Uncouple G-protein regulated processes in the cell membrane of inflammatory cells. This reduces their responsiveness to some agonists released by damaged tissue


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